Alterations in the Levels of Some Serum Enzymes and Liver RNA in Guinea Pigs Treated with Bonny Light Crude Oil
Аннотация
The Bonny light crude oil contains an aromatic and aliphatic fraction in the ratio 1:4 and is the major form prevalent in the Niger Delta region of Nigeria. The intraperitoneal-administration of Bonny light crude to guinea pigs has been associated with alterations in liver chromatin proteins, liver mitochondria and nuclear DNA. This current study was aimed at investigating the changes the intraperitoneal-administration of the Bonny light crude oil could cause to some serum enzymes and RNA in nuclear and mitochondrial fractions of guinea pig liver. The results revealed that the Bonny light crude oil caused marked elevations in the levels of alanine aminotransaminase, aspartate aminotransaminase, and alkaline phosphatase in serum which was dosedependent suggestive of hepatic damage. The liver nuclear and mitochondrial RNA was also increased in a dosedependent manner. The findings are ascribed to the interference of the polycyclic hydrocarbons, heavy metals, and other chemical groups in crude oil which interacted with critical molecules on liver and the subsequent upregulation of the transcription of xenobiotic metabolizing enzymes.
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